The win was the third of the season for the Roush Fenway Racing driver, who started the race 11th in the points standings.
Martin Truex Jr. of Michael Waltrip Racing finished second, and Paul Menard of Richard Childress Racing was third. Fourth was Kasey Kahne of Hendrick Motorsports while Tony Stewart of Stewart Haas Racing was fifth.
Rounding out the top 10 were Clint Bowyer, Regan Smith, Brad Keselowski, Jimmie Johnson and Jeff Gordon.
With four races to go in the season, Keselowski will head to Martinsville next week with a seven-point lead in the standings over Johnson - who was involved in a major wreck but stayed on the lead lap thanks to an impressive repair job by his pit crew. Third in the standings is Denny Hamlin, who finished 13th Sunday. Hamlin will be 20 points back when the Martinsville short track race begins.
Sunday's race featured a track-record 14 cautions. The 14 cautions were also the most in a Sprint Cup race this season.
Those wrecks started early and tore up a large number of cars - 16 of which were in the garages when the race ended.
Kenseth, who suffered sizable damaged early in the race, had the lead when the race restarted after caution with 45 laps to go.
He had a two-plus-second lead when the record-breaking 14th caution came out when Sam Hornish Jr. found the wall with 32 laps to go.
Kenseth survived the restart after that caution and led the rest of the way. His margin of victory over Truex Jr. was .495 seconds.
Notes: Unlike the past couple of years, Carl Edwards, a native of nearby Columbia, Mo., is not a contender for the Cup championship this year. It was quite apparent during pre-race driver introductions that he has not been forgotten, however. Edwards got huge applause when he was introduced. With Dale Earnhardt Jr. not racing because of a concussion, he probably got the second-biggest response from the crowd. First? It appeared that Edwards, who finished second in last year's Chase, was shaded by Bowyer. Bowyer is from Emporia, Kan., which is about an hour-and-a-half drive away. Bowyer also was a multiple track champion at Lakeside Speedway, a dirt short track located just five miles up the road from Kansas Speedway...During the pre-race driver's meeting, there was some confusion expressed by a couple drivers about where they were supposed to blend from the apron onto the track when exiting the pits. The confusion was a result of the reconfiguring of the 1.5-mile oval. David Hoots, NASCAR's managing event director, initially told drivers that blend point was after Turn 2. One driver asked where that exactly was. Hoots could not get specific. Word later came down to teams that that meant where the grass ends....On lap 155, Danica Patrick was involved in a wreck with Landon Cassill. Patrick hit Cassill from behind and later would admit to doing it on purpose. On his two-way radio, Cassill said, "Rule No. 1 in stock car racing is learning how to wreck someone without wrecking yourself."