New England Patriots owner Robert Kraft is certainly a fan of the idea, as his outfit prepare for their second visit to Wembley.
In quotes on the NFL's international website, Kraft says the game is in danger of "tapping out" in the States due to increased popularity.
"If you look at the last Super Bowl in this past season, we had over 180 million people watching -- that's almost two-thirds of America," he said.
"So for us to grow the game, we have to expand globally. I think I said that the last time we were over here in 2009 and before this next decade is out, I hope we have a team here.
"I think that would be right for the NFL and this fan base has proven they deserve it."
The NFL isn't the only U.S. sport to travel to Europe in search of greater riches.
The NBA staged its first regular season game in London in March 2011 -- the 16th it has played on foreign soil in countries such as Japan and Mexico. The NHL has also dipped its toe in the Thames, holding the first regular season match in 2007.
It's not just American sports seeking worldwide expansion, but some of these plans haven't gone down as well as the NFL's proposal.
Soccer club Barcelona, for example, refused to play the preseason Super Cup in Beijing, despite the Spanish league having signed a deal with a Chinese promoter.
Barca said China was too far away for club members who might want to attend the game, though it did acknowledge China represents an "attractive market."
There was a strong backlash against the idea of a 39th English Premier League match to be held overseas when the possibility was mooted several years ago, as domestic fans bridled at the prospect that administrators might tamper with their beautiful game.
But Italian sides Juventus and Napoli had no such qualms, as they contested the Italian Super Cup in Beijing's Bird's Nest Stadium back in August.
Chadwick added: "Increasingly, it is a trend for sports to take their domestic games abroad, from Italian football's Super Cup, to Formula One with races in places like India. The long-term sustainability of some sports increasingly appears to be dictated by an ability to successfully internationalize and globalize.
"The Premier League clubs already do this themselves; the Premier League trophy has been held in Asia, and UEFA market the Champions League heavily in other countries.
"Nevertheless there is a sense of inevitability about the previously mentioned 39th game that it will return to the agenda sometime soon.
"For the Premier League to compete with other sporting properties, it will be looking at overseas markets and how best to take advantage of the opportunities they potentially present."