One elephant in the room: Will he address recent controversial comments made by Republican Sen. Pat Toomey? The senator from Pennsylvania told a local newspaper this week that Republicans voted against the background check bill to prevent the president from winning a legislative victory.
"In the end, it didn't pass because we're so politicized. There were some on my side who did not want to be seen helping the president do something he wanted to get done, just because the president wanted to do it," Toomey said.
His comments seemed to suggest that many in the GOP actually favored an expanded background check system but voted against it for political purposes.
"The toughest thing to do in politics is to do the right thing when your supporters think the right thing is something else," he added.
If not LaPierre, perhaps other speakers may attempt to knock down Toomey's argument. Several potential contenders for the 2016 GOP nomination will take the stage, including Sen. Ted Cruz of Texas, Louisiana Gov. Bobby Jindal, Texas Gov. Rick Perry, former Sen. Rick Santorum of Pennsylvania, and Wisconsin Gov. Scott Walker.
Former vice presidential nominee Sarah Palin will also speak Friday. The former Alaska governor is well known for her love of hunting and the outdoors. Delivering a rousing speech at a major conservative gathering in March, Palin shared an anecdote about her husband buying her a rifle rack for Christmas, while she bought him a gun.
"This go-around, he's got the rifle, I've got the rack," she joked.
Also on the schedule this weekend will be the installment of the group's new president. As part of its formal rotation, Alabama attorney Jim Porter will take the top spot beginning Monday, replacing current President David Keene, whose two-year term concludes at this weekend's gathering.
Porter has been serving as the NRA's first vice president, and before that he served as the group's second vice president. The presidency, an unpaid position, is the next stop in the NRA's leadership rotation.