Federal agents zeroed in Tuesday on how the Boston Marathon bombing was carried out - with kitchen pressure cookers packed with explosives, nails and other lethal shrapnel - but said they still didn't know who did it and why.
An intelligence bulletin issued to law enforcement and released late Tuesday includes a picture of a mangled pressure cooker and a torn black bag the FBI says were part of a bomb.
The FBI and other law enforcement agencies repeatedly pleaded for members of the public to come forward with photos, videos or anything suspicious they might have seen or heard.
"The range of suspects and motives remains wide open," Richard DesLauriers, FBI agent in charge in Boston, said at a news conference. He vowed to "go to the ends of the Earth to identify the subject or subjects who are responsible for this despicable crime."
President Barack Obama branded the attack an act of terrorism but said officials don't know "whether it was planned and executed by a terrorist organization, foreign or domestic, or was the act of a malevolent individual."
Scores of victims of the Boston bombing remained in hospitals, many with grievous injuries, a day after the twin explosions near the marathon's finish line killed three people, wounded more than 170 and reawakened fears of terrorism. A 9-year-old girl and 10-year-old boy were among 17 victims listed in critical condition.
Heightening jitters in Washington, where security already had been tightened after the bombing, a letter addressed to a senator and poisoned with ricin or a similarly toxic substance was intercepted at a mail facility outside the capital, lawmakers said.
There was no immediate indication the episode was related to the Boston attack. Senate Majority Leader Harry Reid said the letter was sent to Republican Sen. Roger Wicker of Mississippi.
Officials found that the bombs in Boston consisted of explosives put in ordinary, 1.6-gallon pressure cookers, one with shards of metal and ball bearings, the other with nails, according to a person close to the investigation who spoke on condition of anonymity because the probe was still going on.
Both bombs were stuffed into black duffel bags and left on the ground, the person said.
DesLauriers confirmed that investigators had found pieces of black nylon from a bag or backpack and fragments of BBs and nails, possibly contained in a pressure cooker. He said the items were sent to the FBI laboratory at Quantico, Va., for analysis.
The FBI said it is looking at what Boston television station WHDH said are photos sent by a viewer that show the scene right before and after the bombs went off. The photo shows something next to a mailbox that appears to be a bag, but it's unclear what the significance is.
"We're taking a look at hundreds of photos and that's one of them," said Jason Pack, FBI spokesman in Boston.
Investigators said they have not yet determined what was used to set off the explosives.
Pressure-cooker explosives have been used in international terrorism, and have been recommended for lone-wolf operatives by Al-Qaida's branch in Yemen.
But information on how to make the bombs is readily found online, and U.S. officials said Americans should not rush to judgment in linking the attack to overseas terrorists.
DesLauriers said there had been no claim of responsibility for the attack.
He urged people to come forward with anything suspicious, such as hearing someone express an interest in explosives or a desire to attack the marathon, seeing someone carrying a dark heavy bag at the race, or hearing mysterious explosions recently.
"Someone knows who did this," the FBI agent said.
The bombs exploded 10 or more seconds apart, tearing off victims' limbs and spattering streets with blood, instantly turning the festive race into a hellish scene of confusion, horror and heroics.
The blasts killed 8-year-old Martin Richard of Boston, 29-year-old Krystle Campbell of Medford, Mass., and a third victim, identified only as a graduate student at Boston University.
Doctors who treated the wounded corroborated reports that the bombs were packed with shrapnel intended to cause mayhem.
"We've removed BBs and we've removed nails from kids. One of the sickest things for me was just to see nails sticking out of a little girl's body," said Dr. David Mooney, director of the trauma center at Boston Children's Hospital.
At Massachusetts General Hospital, all four amputations performed there were above the knee, with no hope of saving more of the legs, said Dr. George Velmahos, chief of trauma surgery.
"It wasn't a hard decision to make," he said. "We just completed the ugly job that the bomb did."