The first brewery in Massachusetts emerged not long after the Pilgrims dropped anchor, owing to the fact that beer was safer to drink than the water. Though the Pilgrims were aiming for Virginia, they ran out of brew and stopped in Massachusetts -- thus a beer town was born.
Eventually, Boston was blessed with a number of microbreweries, including the best-selling craft brewer in America, Boston Beer Co. -- producer of Samuel Adams -- and Harpoon Brewery. Notable hits on the bar crawl include Cambridge and Cape Ann Brewing Cos., Deep Ellum and The Publick House, alongside historic pubs like Green Dragon, The Warren Tavern (Boston's oldest) and Sunset Grill & Tap.
With this lively scene, it's not hard to believe that Boston consumes the most beer per capita in the United States. It's also home to the American Craft Beer Fest, the East Coast's largest celebration of domestic micros, featuring 600+ varieties from 125+ American brewers.
Top draws: Harpoon IPA, Beer Works Bunker Hill Blueberry Ale
History: 7 Breweries: 8 Bars: 7 Events: 8
Colorado is fourth out of 50 states in breweries per capita, and while there are only a handful in Denver proper, there are loads of notable breweries outside town and in nearby Boulder.
Neighborhoods like Platte Street and the Art District on Santa Fe are peppered with breweries. Elsewhere you'll find Avery, Renegade, New Belgium, Strange Brewing, Dry Dock and others, including Bull & Bush, which writer Steve Body declared "may well be America's best brewpub and restaurant."
Denver's first craft brewery, Wynkoop, was opened in 1988 by John Hickenlooper, who went on to become mayor, then governor, extending Denver's brewer reach to the highest levels of government. Both Wynkoop and Great Divide are a moon shot from Coors Field, and homemade beers at Blue Moon Brewing Co. are found just behind section 112 in left field.
The Mile-High City also stages what is widely regarded the largest, most prestigious beer festival in the country, the annual Great American Beer Festival, drawing sudsmeliers from all over the world to taste more than 2,200 brews.
Top Draws: Denver Graham Cracker Porter, Renegade Hammer and Sickle
History: 9 Breweries: 6 Bars: 8 Events: 7
In the city of brewery love, outfits like Victory, Sly Fox, Nodding Head, Yards and Flying Fish have been vanguards of local brewing since the city's barley rush of the 1990s. And since 1860, McGillin's Olde Ale House has been a beloved showcase for those and other local brews longer than any in Philly.
Three less-ancient bars made Draft mag's top 100 -- Eulogy Belgian Tavern, Grey Lodge Public House and Memphis Taproom, which enjoys a sterling reputation despite an endorsement by Guy Fieri. And no beer itinerary is complete without writer Michael Jackson's favorite spot, Monk's Cafe, a love letter to Belgian (and other) brews that will awe the savviest palate.
Philly Beer Week is the city's most hoppening event, but the Greater Northeast Philadelphia Beer Festival, begun in 2011, is already proving a worthy companion. One caveat to all this beer-fueled euphoria: complicated state controls regulate the purchase of packaged beer. Don't let them kill your buzz.
Top Draws: Yards Philadelphia Pale Ale, Victory Hop Devil IPA
7. Bend, Oregon
History: 5 Breweries: 8 Bars: 8 Events: 8
With one brewery for every 9,111 people, descriptors for Bend include "beervana" and "Beer City, USA." And that number is constantly changing, with newcomers like Crux Fermentation Project and Worthy Brewing Company recently fattening Bend's ranks.
Already cemented into Bend beer culture is Deschutes, the godfather of local craft brewing, which recently expanded its flagship location. The Ale Apothecary, like its name suggests, blends modern and old-fashioned brewing techniques for what they're calling Bend's only steampunk brewery.
Getting your beer passport stamped at all nine of participating breweries on the Bend Ale Trail will net you a prize, and dog lovers will appreciate Boneyard Beer, where they can try the world's first organic, non-alcoholic brew made for dogs, Dawg Grogg.
Your itinerary's bound to overlap at least one of Bend's annual beer celebrations, like Central Oregon Beer Week, The Little Woody Barrel-Aged Brew & Whiskey Festival, Bend BrewFest, The Fermentation Celebration and Bend Oktoberfest.
Top Draws: Deschutes Inversion IPA, Silver Moon Hound's Tooth Amber
8. Asheville, North Carolina